abstract：AIMS:Changes in serotonergic sensory modulation associated with overexpression of 5-HT3 receptors in the central nervous system (CNS) have been implicated in the pathophysiology of neuropathic pain after peripheral nerve damage. 5-HT3 receptor antagonists such as ondansetron can potentially alleviate neuropathic pain, ...

journal_title：British journal of clinical pharmacology

authors： Chiang MD,Frey K,Lee C,Kharasch ED,Tallchief D,Sawyer C,Blood J,Back H,Kagan L,Haroutounian S

更新日期：2020-06-04 00:00:00

abstract：AIMS:Therapeutic drug monitoring of infliximab can guide clinical decisions in patients with loss of response and in those who can benefit from a de-intensification. The aim of this study was to determine the impact of therapeutic drug monitoring combined with Bayesian forecasting methodology on clinical response in a ...

journal_title：British journal of clinical pharmacology

authors： Santacana Juncosa E,Rodríguez-Alonso L,Padullés Zamora A,Guardiola J,Rodríguez-Moranta F,Serra Nilsson K,Bas Minguet J,Morandeira Rego F,Colom Codina H,Padullés Zamora N

更新日期：2020-06-03 00:00:00

abstract：AIMS:To compare the airway potency, systemic activity and therapeutic index of three inhaled corticosteroids that differ in glucocorticoid receptor binding affinity, physicochemical and pharmacokinetic properties. METHODS:This escalating-dose, placebo-controlled, cross-over study randomised adults with asthma to 1 or ...

journal_title：British journal of clinical pharmacology

authors： Daley-Yates P,Brealey N,Thomas S,Austin D,Shabbir S,Harrison T,Singh D,Barnes N

更新日期：2020-06-02 00:00:00

abstract：AIM:Sunitinib is an oral tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST). Because of the large interpatient pharmacokinetic variability and established exposure-response and exposure-toxicity relationships in clinical trial patients, therapeut...

journal_title：British journal of clinical pharmacology

authors： Westerdijk K,Krens SD,van der Graaf WTA,Mulder SF,van Herpen CML,Smilde T,van Erp NP,Desar IME

更新日期：2020-05-01 00:00:00

abstract：AIMS:Within the new psychoactive substances (NPS) scenario, several hundred different molecules, mostly including synthetic cannabinoids and cathinones, have been identified so far. The aims of the paper were to: (i) identify the number of synthetic cathinones mentioned in a range of psychonaut, NPS-related, online sou...

journal_title：British journal of clinical pharmacology

authors： Schifano F,Napoletano F,Arillotta D,Zangani C,Gilgar L,Guirguis A,Corkery JM,Vento A

更新日期：2020-03-01 00:00:00

abstract：AIMS:The effects of biologics on reproduction/lactation are mostly unknown although many patients that receive biologics are women of reproductive age. The first objective of this study was to investigate the publicly available data on pregnancy/lactation before and after marketing authorization in Europe of biologics ...

journal_title：British journal of clinical pharmacology

authors： Ghalandari N,Dolhain RJEM,Hazes JMW,Siezen CLE,van der Laan JW,Crijns HJMJ,van Puijenbroek EP,van der Woude CJ

更新日期：2020-03-01 00:00:00

abstract：AIMS:To explore the feasibility of delivering community-based drug safety testing (drug checking), to trial service design characteristics and to compare with festival-based testing. METHODS:In total, 171 substances of concern were submitted on 5 dates at 3 venues in 2 UK cities and tested using up to 6 analytical tec...

journal_title：British journal of clinical pharmacology

authors： Measham F

更新日期：2020-03-01 00:00:00

abstract：AIMS:To assess whether hospitalization may assist in correcting errors in anticoagulant therapy among patients with atrial fibrillation (AF). METHODS:Our cohort included patients admitted to our institution with a history of AF between 2016 and 2018. We categorized patient's treatment upon admission and discharge as l...

journal_title：British journal of clinical pharmacology

authors： Angel Y,Zeltser D,Berliner S,Ingbir M,Shapira I,Shenhar-Tsarfaty S,Rogowski O

更新日期：2019-12-01 00:00:00

abstract：:Acute myeloid leukaemia (AML) is a haematopoietic stem cell disorder, that is characterized by the clonal expansion of myeloid blasts and suppression of normal haematopoiesis. The 3 + 7 regimen is the backbone of standard first-line induction therapy among young/fit patients. However, in elderly and/or unfit patients ...

journal_title：British journal of clinical pharmacology

authors： Kucukyurt S,Eskazan AE

更新日期：2019-12-01 00:00:00

abstract：AIMS:The objective of this study is to develop a generic model for tacrolimus pharmacokinetics modelling using a meta-analysis approach, that could serve as a first step towards a prediction tool to inform pharmacokinetics-based optimal dosing of tacrolimus in different populations and indications. METHODS:A systemati...

journal_title：British journal of clinical pharmacology

authors： Nanga TM,Doan TTP,Marquet P,Musuamba FT

更新日期：2019-12-01 00:00:00

abstract：AIMS:The objectives were to investigate the pharmacokinetics, pharmacodynamics and safety of ilaprazole infusion in healthy subjects and patients with esomeprazole as positive control, and then recommend the dosage regimen for Phase 2b/3 studies. METHODS:Three clinical studies were performed. First, 16 healthy subject...

journal_title：British journal of clinical pharmacology

authors： Wang H,Shao F,Liu X,Xu W,Ou N,Qin X,Liu F,Hou X,Hu H,Jiang J

更新日期：2019-11-01 00:00:00

abstract：:Vertigo is associated with a wide range of vestibular pathologies. It increasingly affects the elderly, with a high cost to society. Solutions include vestibular suppressants and vestibular rehabilitation, which form the mainstay of therapy. Antihistamines represent the largest class of agents used to combat vestibula...

journal_title：British journal of clinical pharmacology

authors： Dyhrfjeld-Johnsen J,Attali P

更新日期：2019-10-01 00:00:00

abstract：AIMS:Drug disposition in children may vary from adults due to age-related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [14 C]midazolam microdose, b...

journal_title：British journal of clinical pharmacology

authors： van Groen BD,Vaes WH,Park BK,Krekels EHJ,van Duijn E,Kõrgvee LT,Maruszak W,Grynkiewicz G,Garner RC,Knibbe CAJ,Tibboel D,de Wildt SN,Turner MA

更新日期：2019-10-01 00:00:00

abstract：AIMS:To individualize treatment, phenytoin doses are adjusted based on free concentrations, either measured or calculated from total concentrations. As a mechanistic protein binding model may more accurately reflect the protein binding of phenytoin than the empirical Winter-Tozer equation that is routinely used for cal...

journal_title：British journal of clinical pharmacology

authors： Ter Heine R,Kane SP,Huitema ADR,Krasowski MD,van Maarseveen EM

更新日期：2019-10-01 00:00:00

abstract：AIMS:To develop and evaluate a feasible, authentic pharmacist-led prescribing feedback intervention for doctors-in-training, to reduce prescribing errors. METHODS:This was a mixed methods study. Sixteen postgraduate doctors-in training, rotating though the surgical assessment unit of 1 UK hospital, were filmed taking ...

journal_title：British journal of clinical pharmacology

authors： Parker H,Farrell O,Bethune R,Hodgetts A,Mattick K

更新日期：2019-10-01 00:00:00

abstract：:Regulating drugs does not end when market access has been granted. Monitoring drugs over the life cycle has become state of the art, inherent to evolving legislation and societal need. Here, we explore how the drug label could move along in a changing playing-field and become a sustainable label for the future. A dial...

journal_title：British journal of clinical pharmacology

authors： Gispen-de Wied CC,Weemers J,Boon W,Mol PGM,Stolk P

更新日期：2019-10-01 00:00:00

abstract：AIMS:Sulfonylureas are recommended as second-line treatment in the management of type 2 diabetes. However, they are still commonly used also as first-line treatment instead of metformin. Given the controversial cardiovascular safety of sulfonylureas, we aimed to determine if their use as first-line treatment is associa...

journal_title：British journal of clinical pharmacology

authors： Filion KB,Douros A,Azoulay L,Yin H,Yu OH,Suissa S

更新日期：2019-10-01 00:00:00

abstract：:Phenytoin drug reaction with eosinophilia and systemic symptoms (DRESS) in 3 Aboriginal Australians positive for HLA-B*56:02 has been previously reported. We report the allele frequency of HLA-B*56:02 in 2 South Australian populations, 1 Aboriginal (4.8%, 95% confidence interval 2.4-7.8%) and the other European (0%). ...

journal_title：British journal of clinical pharmacology

authors： Somogyi AA,Barratt DT,Phillips EJ,Moore K,Ilyas F,Gabb GM

更新日期：2019-09-01 00:00:00

abstract：AIMS:Generic products can be regarded as therapeutically equivalent and switchable with the reference product. However, switchability between generics is unknown, as direct comparisons between generics are not performed. The aim of this study was to investigate the bioequivalence between generic clopidogrel products by...

journal_title：British journal of clinical pharmacology

authors： Pejčić Z,Vučićević K,García-Arieta A,Miljković B

更新日期：2019-09-01 00:00:00

abstract：AIMS:In 2017, concerns regarding adverse events (AEs) associated with the Mirena levonorgestrel intrauterine device were largely echoed in the media in France. This resulted in a tremendous reporting of AEs to pharmacovigilance centres. The aim of this study was to describe the reporting of AEs regarding Mirena in Fran...

journal_title：British journal of clinical pharmacology

authors： Langlade C,Gouverneur A,Bosco-Lévy P,Gouraud A,Pérault-Pochat MC,Béné J,Miremont-Salamé G,Pariente A,French Network of Pharmacovigilance Centres.

更新日期：2019-09-01 00:00:00

abstract：:Cyclophosphamide is an alkylating agent used in the treatment of solid and haematological malignancies and as an immunosuppressive agent. As a prodrug, it is dependent on bioactivation to the active phosphoramide mustard metabolite to elicit its therapeutic effect. This focused review will highlight the evidence for t...

journal_title：British journal of clinical pharmacology

authors： Helsby NA,Yong M,van Kan M,de Zoysa JR,Burns KE

更新日期：2019-09-01 00:00:00

abstract：:There is concern in the UK about nonmedical use (NMU) of alprazolam (Xanax). We investigated the epidemiology of alprazolam NMU compared with diazepam using data from the Survey of Non-Medical Use of Prescription Drugs (NMURx) programme (collected 28 September-1 December 2017). The survey included 10 019 respondents a...

journal_title：British journal of clinical pharmacology

authors： Hockenhull J,Amioka E,Black JC,Haynes CM,Dargan PI,Dart RC,Wood DM

更新日期：2019-08-01 00:00:00

abstract：AIMS:Navoximod (GDC-0919, NLG-919) is a small molecule inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), developed to treat the acquired immune tolerance associated with cancer. The primary objectives of this study were to assess navoximod's absolute bioavailability (aBA), determine the mass balance and routes of elim...

journal_title：British journal of clinical pharmacology

authors： Ma S,Suchomel J,Yanez E,Yost E,Liang X,Zhu R,Le H,Siebers N,Joas L,Morley R,Royer-Joo S,Pirzkall A,Salphati L,Ware JA,Morrissey KM

更新日期：2019-08-01 00:00:00

abstract：AIMS:To investigate presence or absence of clinically relevant drug interactions (pharmacokinetic and safety/tolerability) of OBE022 with standard-of-care medicines for preterm labour, enabling coadministration and further clinical development. METHODS:Part A: open-label, randomized, 3-period crossover assessing coadm...

journal_title：British journal of clinical pharmacology

authors： Pohl O,Marchand L,Gotteland JP,Coates S,Täubel J,Lorch U

更新日期：2019-07-01 00:00:00

abstract：AIMS:Our study aimed to evaluate the impacts of the cytochrome P450 (CYP) 2B6-G516T and CYP2D6 genetic polymorphisms on pharmacokinetic and clinical parameters in patients receiving methadone maintenance treatment. METHODS:Opioid PhArmacoLogy (OPAL) was a clinical survey of the sociodemographic characteristics, histor...

journal_title：British journal of clinical pharmacology

authors： Victorri-Vigneau C,Verstuyft C,Bouquié R,Laforgue EJ,Hardouin JB,Leboucher J,Le Geay B,Dano C,Challet-Bouju G,Grall-Bronnec M

更新日期：2019-07-01 00:00:00

abstract：AIMS:Data regarding the cardiac toxicity of cabozantinib lacks. The aim of our study was to assess the risk of cabozantinib-related cardiotoxicity in mRCC patients. METHODS:We performed a multicentre prospective study on mRCC patients treated with cabozantinib between October 2016 and November 2017. Transthoracic echo...

journal_title：British journal of clinical pharmacology

authors： Iacovelli R,Ciccarese C,Fornarini G,Massari F,Bimbatti D,Mosillo C,Rebuzzi SE,Di Nunno V,Grassi M,Fantinel E,Ardizzoni A,Tortora G

更新日期：2019-06-01 00:00:00

abstract：AIMS:Reduced nitric oxide (NO) availability may adversely affect renal perfusion and glomerular filtration. The aim of the present study was to characterize in detail the pharmacological effects of VAS203, an inhibitor of NO synthase, on renal haemodynamics in humans. METHODS:This double-blind, randomized, placebo-con...

journal_title：British journal of clinical pharmacology

authors： Ott C,Bosch A,Winzer N,Friedrich S,Schinzel R,Tegtmeier F,Schmieder RE

更新日期：2019-05-01 00:00:00

abstract：:Adopted guidelines reflect a harmonised European approach to a specific scientific issue and should reflect the most recent scientific knowledge. However, whilst EU regulations are mandatory for all member states and EU directives must be followed by national laws in line with the directive, EMA guidelines do not have...

journal_title：British journal of clinical pharmacology

authors： Ollivier C,Thomson A,Manolis E,Blake K,Karlsson KE,Knibbe CAJ,Pons G,Hemmings R

更新日期：2019-04-01 00:00:00

abstract：AIMS:Surgical site infections contribute to morbidity and mortality after surgery. The authors hypothesized that higher antibiotic tissue concentrations can be reached for a prolonged time span by continuous administration of prophylactic cefuroxime compared to bolus administration. METHODS:Twelve patients undergoing ...

journal_title：British journal of clinical pharmacology

authors： Skhirtladze-Dworschak K,Hutschala D,Reining G,Dittrich P,Bartunek A,Dworschak M,Tschernko EM

更新日期：2019-04-01 00:00:00

abstract：AIMS:The aim of this study was to examine the use of potentially inappropriate medication (PIM) in relation to time before death, to explore whether PIMs are discontinued at the end of life, and the factors associated with this discontinuation. METHODS:We conducted a retrospective register-based mortality cohort study...

journal_title：British journal of clinical pharmacology

authors： Paque K,De Schreye R,Elseviers M,Vander Stichele R,Pardon K,Dilles T,Christiaens T,Deliens L,Cohen J

更新日期：2019-04-01 00:00:00

abstract：ADVERSE EVENT:Repeated and prolonged episodes of central apnoea and hypoxia after receiving intravenous morphine for analgesia and ketamine for sedation. DRUG IMPLICATED:Intravenous morphine sulfate. THE PATIENT:Previously healthy 12-year-old male with no history of sleep apnoea who presented with distal tibia and fi...

journal_title：British journal of clinical pharmacology

authors： Toce MS,Kim H,Chung S,Krauss BS

更新日期：2019-01-01 00:00:00

abstract：AIMS:Infection-induced inflammation is associated with adverse long-term outcomes in preterm infants. Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but pharmacokinetic data in this population are extremely li...

journal_title：British journal of clinical pharmacology

authors： Salman S,Hibbert J,Page-Sharp M,Manning L,Simmer K,Doherty DA,Patole S,Batty KT,Strunk T

更新日期：2019-01-01 00:00:00

abstract：AIMS:To evaluate the potential ethnic differences in the pharmacokinetics (PK) and pharmacodynamics (PD) of evolocumab in Caucasian and Asian populations using population PK/PD modelling analysis. METHODS:Data from different ethnic groups in 5 Phase I clinical trials, including two American studies, one Japanese study...

journal_title：British journal of clinical pharmacology

authors： Wang C,Zheng Q,Zhang M,Lu H

更新日期：2019-01-01 00:00:00

abstract：AIM:Pharmacokinetics of small molecule kinase inhibitors (KIs) used in cancer treatment may alter with increasing age, but results are conflicting. This study aims to compare exposure to KIs between older and younger patients (≥70 and <70 years) in clinical practice. METHODS:KI plasma concentrations of routinely treat...

journal_title：British journal of clinical pharmacology

authors： Crombag MBS,van Doremalen JGC,Janssen JM,Rosing H,Schellens JHM,Beijnen JH,Steeghs N,Huitema ADR

更新日期：2018-12-01 00:00:00

abstract：AIMS:SNF472 is a calcification inhibitor being developed for the treatment of cardiovascular calcification in haemodialysis (HD) and in calciphylaxis patients. This study investigated the safety, tolerability and pharmacokinetics (PK) of intravenous (IV) SNF472 in healthy volunteers (HV) and HD patients. METHODS:This ...

journal_title：British journal of clinical pharmacology

authors： Perelló J,Joubert PH,Ferrer MD,Canals AZ,Sinha S,Salcedo C

更新日期：2018-12-01 00:00:00

abstract：:Model-based prediction on clinical doses for cannabinoids therapy is beneficial in the clinical setting, especially for seriously ill patients with both altered pharmacokinetics and pharmacodynamic responses. The objective of this article is to review the currently available PK and/or PD models of Δ9-tetrahydrocannabi...

journal_title：British journal of clinical pharmacology

authors： Liu Z,Martin JH

更新日期：2018-11-01 00:00:00

abstract：AIMS:Increased exposure to fondaparinux, as observed in patients with renal impairment, may increase bleeding risk. This study aims to determine the time course of major bleeding after major orthopaedic surgery, identify predictors of bleeding and simulate the effect of a reduced dose of fondaparinux on bleeding for pa...

journal_title：British journal of clinical pharmacology

authors： Zufferey PJ,Ollier E,Delavenne X,Laporte S,Mismetti P,Duffull SB

更新日期：2018-10-01 00:00:00

abstract：:People who are 60 years old and older have the highest incidence of developing new-onset epilepsy. The increase of the ageing population has resulted in a greater number of patients with new-onset epilepsy or at risk of developing the condition. Previously published review articles regarding epilepsy in older patients...

journal_title：British journal of clinical pharmacology

authors： Vu LC,Piccenna L,Kwan P,O'Brien TJ

更新日期：2018-10-01 00:00:00

abstract：AIMS:Previous pharmacokinetic characterization of a transporter probe cocktail containing digoxin (P-gp), furosemide (OAT1, OAT3), metformin (OCT2, MATE1, MATE2-K) and rosuvastatin (OATP1B1, OATP1B3, BCRP) in healthy subjects showed increases in rosuvastatin systemic exposure compared to rosuvastatin alone. In this tri...

journal_title：British journal of clinical pharmacology

authors： Stopfer P,Giessmann T,Hohl K,Hutzel S,Schmidt S,Gansser D,Ishiguro N,Taub ME,Sharma A,Ebner T,Müller F

更新日期：2018-09-01 00:00:00

abstract：AIMS:The pharmacokinetics (PK) of fluconazole and micafungin differ in neonates compared with children and adults. Dosing instructions in product labels appear to be inconsistent with the emerging scientific evidence. Limited information is available on the safety profile of these agents in neonates. Our objective was ...

journal_title：British journal of clinical pharmacology

authors： Leroux S,Jacqz-Aigrain E,Elie V,Legrand F,Barin-Le Guellec C,Aurich B,Biran V,Dusang B,Goudjil S,Coopman S,Garcia Sanchez R,Zhao W,Manzoni P,FP7 TINN (Treat Infections in NeoNates) consortium.

更新日期：2018-09-01 00:00:00